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ORLAAM has been shown to prolong the ST segment of the electrocardiogram in beagle dogs dosed 5 days a week, and to inhibit the quickly-activating delayed rectifier present I Kr in isolated myocytes in vitro Serial EKGs performed in a human pharmacokinetics study showed a prolongation of the QTc interval in some patients which was not connected with dose.
Such individuals should stay below prolonged observation rather than being allowed to leave emergency remedy, given that ORLAAM's action will outlast naloxone-induced reversal, putting the unsupervised patient at threat of relapse , a return of respiratory depression and attainable death if continuing health-related consideration is not accessible.
